Discovery of p53 tetramer stabilization peptides

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Proyecto asignado a través de la Red Española de Supercomputación.

Tetramer formation of p53 (TP53) is essential for its tumor suppressor function. The p53 not only acts as a tumor suppressor protein by inducing cell cycle arrest and apoptosis. More than 50% of human tumors have TP53 gene mutations, and most of them are missense mutations that reduce tumor suppressor activity of p53 by destabilizing the TP53 formation. A new therapeutical intervention where an active peptide is able to stabilize TP53 tetramers and re-store functional protective activity of p53 is pursued in this project by combining state-of-the-art experimental and computational approaches.